Other possible negative effects of estrogen include: Vaginal bleeding or spotting Abdominal pains Poor sleeping habit Skin rashes Depression Head aches, migraine headaches Causes endometrial cancer Therefore, with both of these positive and negative effects presented, the decision in taking estrogen will not be all yes . Compared to other normal estrogen producing individuals, these people produces small amount of menstruation. It can also be a reason for some emotional problems like depression and aggression towards other people with no valid reason. This is why maintaining a normal estrogen is essential especially to women. These signs and symptoms are difficulty of breathing, arrhythmia, high blood pressure and paralysis of half of the body. Usually, the over production of estrogen increases the blood pressure that can be the main cause of stroke. Most of the scientists believe that over production of estrogen can affect the normal function of the heart, which can cause some serious heart ailments. In addition, as the adult population increases, the number of estrogen deficient women will also increase. There is an increasing alarm that many of these affected women will not have a chance to be treated for estrogen deficiency. A correct management of estrogen deficiency should be taken into consideration since this deficiency can give permanent problems to the affected person. This hormone is found in both men and women but women of reproductive age have high levels of it. Estrogen hormone helps in developing the breast of the women, thickening of the endometrial, affects the discharge of hormones from pituitary gland and changing the menstrual cycle. There are a total of six estrogenic substances in the women s body. Many scientific studies were launched regarding its beneficial result as well as its adverse effect in the human body. Despite its popularity in the market and in the scientific field for curing and preventing various kinds of illness and other afflictions, many issues still abound regarding its very nature.